Home  >  Products  >  Synapsin I, phosphorylated (Ser549) (Synapsin 1, Synapsin-1, SYN1, SYN-1, Synapsin-I, SYNI, SYN-I, Brain Protein 4.1, SYN1a, SYN1b, SYN-1a, SYN-1b)
Synapsin I, phosphorylated (Ser549) (Synapsin 1, Synapsin-1, SYN1, SYN-1, Synapsin-I, SYNI, SYN-I, Brain Protein 4.1, SYN1a, SYN1b, SYN-1a, SYN-1b)

Synapsin I, phosphorylated (Ser549) (Synapsin 1, Synapsin-1, SYN1, SYN-1, Synapsin-I, SYNI, SYN-I, Brain Protein 4.1, SYN1a, SYN1b, SYN-1a, SYN-1b)

Cat no: S9103-90B

Supplier: United States Biological
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Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002; Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation (Jovanovic et al., 2001; Kao et al., 2002). Ser 549 along with Ser 62 and Ser 67 are the sites of Synapsin I that are phosphorylated by MAP kinase (Jovanovic et al., 1996). Phosphorylation and subsequent dephosphorylation of this site is thought to play a key role in synaptic vesicle trafficking. Applications: Suitable for use in Immunohistochemistry, Dot Blot and Western Blot. Other applications not tested. Recommended Dilution: Immunohistochemistry: paraffin sections Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S9103-90B
Reactivities: Human, Mouse, Rat, Bovine, Canine
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in 10mM Hepes, pH 7.5, 150mM sodium chloride, 10mg/ml BSA, 50% glycerol
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
References: 1. Jovanovic JN, et al., (1996) Neurotrophins stimulate phosphorylation of Synapsin I by MAP kinase and regulate SynapsinI-actin interactions. Neurobiology 93:3679-3683.
Additional info: Recognizes rat synapsin I doublet phosphorylated at Ser549. MW: 78kD. Immunolabeling of the Synapsin I band is blocked by lambda-phosphatase treatment. Species sequence homology: human, mouse, primate, bovine and canine.

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