Synaptic adhesion-like molecule 2 (SALM2, LRFN1, leucine rich repeat and fibronectin type III domain containing 1, KIAA1484, Leucine-rich repeat and fibronectin type III domain-containing protein 1)

Synaptic adhesion-like molecule 2 (SALM2; also leucine-rich repeat and fibronectin type-III domain-containing protein 1 (Lrfn1) is a 105kD member of the Lrfn family of type I transmembrane glycoproteins. Human SALM2 is synthesized as a 771aa precursor that contains a 31aa signal sequence, a 505aa extracellular domain, a 21aa transmembrane region, and a 214aa cytoplasmic region. The ECD consists of seven leucine-rich repeats, an IgC2-like domain, and a fibronectin type-III domain, tandemly aligned in that order. In addition, there are two potential sites for N-linked glycosylation. The C-terminal region contains an intracellular PDZ binding domain, which is conserved among SALMs 1-3, but is absent in SALMs 4 and 5. Mature human SALM2 shares 96% and 95% sequence identity with mature mouse and rat SALM2, respectively. \n\nApplications: \nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 0.5-1ug/ml\nWestern Blot: 1ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C for short-term only. Reconstitute with sterile 40-50% glycerol, aliquot and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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