Syndecan-4 (SYND4, Amphiglycan, Ryudocan Core Protein, SDC4)

Syndecan-4 is a transmembrane (type I) heparan sulfate proteoglycan belonging to the syndecan proteoglycan family. Syndecan-4 functions as a receptor or coreceptors in intracellular signaling. The syndecan heparan sulfate chains of Syndecan-4 bind to HIV-1 gp120 and thus functions as trans HIV receptors. Thus endothelial cells lining the vasculature that are rich in Syndecan may provide a microenvironment to boost HIV replication in T cells. Reports suggest that Syndecan-4 is usually upregulated in skin dermis after wounding thus playing an important role in wound healing and angiogenesis. It is also needed in satellite cell function and in the development and regeneration of skeletal muscle.\n\nApplications:\nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:100-1:1000\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

S9111-60A

Size

100ul

Applications

ELISA

Hosts

Rabbit

Reactivities

Hum, Mouse, Bov, Can, Ch/Bird, NHP

Form

Supplied as a liquid, 0.025% sodium azide, 50% glycerol.

P Type

Pab

Purity

Serum.

Isotype

IgG

References

1. Kojima T. et al. Biochem. Biophys. Res. Commun. 190: 814-822 (1993). 2. Echtermeyer F. et al. J. Clin. Invest. 107: R9-R14 (2001). 3. Bobardt M. D. et al. Immunity 18: 27-39 (2003).

Additional Info

Recognizes human Syndecan-4. Species Crossreactivity: chicken, chimpanzee, bovine, canine, equine, monkey, mouse. Species sequence homology: pufferfish, salmon, xenopus, zebrafish.