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Syndecan-4 (SYND4, Amphiglycan, Ryudocan Core Protein, SDC4)

Syndecan-4 (SYND4, Amphiglycan, Ryudocan Core Protein, SDC4)

Cat no: S9111-60B

Supplier: United States Biological
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Syndecan-4 is a transmembrane (type I) heparan sulfate proteoglycan containing 198aa and belonging to the syndecan proteoglycan family. Syndecan-4 functions as a receptor or coreceptor in intracellular signaling. Initially, Syndecan-4 was isolated as ryudocan, from rat endothelial cells, and from human epithelial and fibroblastic cells, as amphiglycan. The syndecan heparan sulfate chains of Syndecan-4 binds to HIV-1 gp120 and thus functions as trans HIV receptors. This cell surface proteoglycan usually exists as a homodimer that interacts with CDCP1, with GIPC PDZ domain and with NUDT16L1/SDOS. Reports suggest that Syndecan-4 is often upregulated in skin dermis after wounding, thus playing an important role in wound healing and angiogenesis. It is also needed in satellite cell function and in the development and regeneration of skeletal muscle. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Jurkat and Raw cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S9111-60B
Reactivities: Human, Mouse, Non-Human Primate
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein A affinity chromatography.
References: 1. Cornelison, D.D.W., et al., Genes Dev. 18: 2231-2236 (2004). 2. Bobardt, M.D., et al., Immunity 18: 27-39 (2003). 3. Echtermeyer, F., et al., J. Clin. Invest. 107: 9-14 (2001).
Additional info: Recognizes human Syndecan-4. Species Crossreactivity: mouse, New World monkey.

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