Syntaxin 13 (Syntaxin-13, SYX 13, SYX13, CG11278, CT31479, DmSyx13, Dm-Syx13, ff16, ff16 (69D1-70A2), l(3)01470)

Syntaxins are type II integral membrane proteins localized to membranes that regulate vesicle transport, protein maturation, and exocytosis. Syntaxin 1A resides in the nerve terminals of sensory neurons and nerve fibers reaching small blood vessels. Syntaxin 2 localizes to the apical plasma membrane and regulates epithelial-mesenchymal interactions. Syntaxin 6 is primarily localized to the trans-Golgi network, and partially co-localizes with AP-1 on clathrin-coated membranes. Syntaxin 13 is ubiquitously expressed and localizes to the tubular early and recycling endosomes, as well as endosomal vacuoles.\n\nApplications: \nSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested. \n\nRecommended Dilutions: \nWestern Blot (Colorimetric): 1:1000\nImmunohistochemistry: Paraffin sections\nOptimal dilutions to be determined by the researcher.\n\nPositive Controls: \nRat Brain Tissue Extract and Mouse Brain Tissue Extract\n\nStorage and Stability: \nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

S9205-45

Size

25ug

Applications

IHC, WB

Hosts

Mouse

Reactivities

Mouse, Rat, Can

Form

Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG

References

1. Advani, R.J., et al. (1998) J. Biol. Chem. 273: 10317-10324. 2. Prekeris, R., Klumperman, J., Chen, Y.A. and Scheller, R.H. (1998) J. Cell Biol. 143: \n957-971. 3. Huang, L; Kuo, YM; Gitschier, J; (1999) Nat Genet 23(3): 329-332.

Additional Info

Recognizes rat Syntaxin 13. Detects an ~38kD protein, corresponding to the apparent molcular mass of syntaxin 13. Species Crossreactivity: mouse, canine and hamster