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Synuclein (A19) pAb

Synuclein (A19) pAb

Cat no: BS1349

Supplier: Bioworld Technology, Inc.
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Alpha Synuclein is implicated in the regulation of dopamine release and transport. It is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). In the nervous system, alpha Synuclein is primarily located at presynaptic terminals and is found membrane bound in dopaminergic neurons. It can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies), including Parkinson's Disease. Alpha Synuclein induces fibrillization of microtubule associated protein tau and reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. Alpha synuclein is a protein phosphorylated predominantly on serine residues.
Catalogue number: BS1349
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P37840
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids N-terminus of Human Synuclein-(alpha).
Species: Synuclein-pan (A19) pAb detects endogenous levels of Synuclein-pan protein.
Molecular weight: ~ 18 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP; pan Synuclein; NACP Non A-beta Component Of AD Amyloid PARK1 PARK4 PD1 SNCA Synuclein Alpha (Non A4 Component Of Amyloid Precursor
Additional info: For research use only, not for use in diagnostic procedure.

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