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Synuclein, alpha

Cat no: S9500-08

Synuclein, alpha

This antibody recognizes a-synuclein, which belongs to a family of small cytoplasmic proteins expressed predominantly in neurons. The epitope maps to amino acid residues 121-125 of human a-synuclein. a-synuclein may be involved in neuronal plasticity and could act as a molecular chaperone that mediates the transformation of soluble AB into insoluble amyloid. The protein is a major component of Lewy bodies, the pathological hallmark of Parkinson

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SPECIFICATIONS

Catalog Number

S9500-08

Size

100ug

Applications

ELISA, IHC, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2, 0.1% BSA, 0.1% sodium azide.

P Type

Mab

Purity

Purified by Protein A/G affinity chromatography.

Isotype

IgG1

References

1. Bruening, W., et al. (2000) Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary. Cancer 88(9):2154-2163. 2. Giasson, B.I., et al. (2000) A panel of epitope-specific antibodies detects protein domains distributed throughout human a-synuclein in Lewy bodies of Parkinson's disease. J. Neurosci. Res. 59(4):528-533 .3. Giasson, B.I. (2000) Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Science 290:985-989. 4. McLean, P. J., et al. (2000) Membrane association and protein conformation of a-synuclein in intact neurons. J. Biol. Chem. 275(12):8812-8816. 5. Okochi, M., et al. (2000) Constitutive phosphorylation of the Parkinson

Additional Info

Recognizes alpha-synuclein (19kD). Species Crossreactivity: Human. Does not crossreact with mouse or rat.

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