Synuclein, gamma (Synuclein gamma, Gamma Synuclein, SNCG, SNCG Protein, Breast Cancer Specific Gene 1, Breast Cancer Specific Gene 1 Protein, BCSG1, Breast Cancer Specific Protein 1, Persyn, PRSN, Synoretin, SR)

Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. SUBUNIT: May be a centrosome-associated protein. \n\nCellular Localization:\nCytoplasm; perinuclear region. Centrosome. Spindle. Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle. \n\nTissue Specificity:\nHighly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung. PTM: Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases. DISEASE: Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCG is found in spheroids but not in inclusions. Belongs to the synuclein family.\n\nApplications: \nSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

S9502-04G

Size

100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Rat

Form

Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material.

P Type

Pab

Purity

Serum

References

1. Lundvig, et al Brain Res Mol Brain Res 134, 3-17 (Mar 24, 2005). ; 2. Bennett, Pharmacol Ther 105, 311-31 (Mar, 2005). ; 3. Vekrellis, et al., Mol Neurobiol 30, 1-21 (Aug, 2004). ; 4. Martin, et al., Protein Pept Lett 11, 229-37 (Jun, 2004). ; 5. Doherty, et al., Acta Neuropathol (Berl) 107, 169-75 (Feb, 2004). ; 6. Goedert, Curr Opin Genet Dev 11, 343-51 (Jun, 2001). ; 7. Saito, et al., J Neurol Sci 177, 48-59 (Aug 1, 2000). ; 8. Lucking, et al., Cell Mol Life Sci 57, 1894-908 (Dec, 2000). ; 9. Kahle, et al., Ann N Y Acad Sci 920, 33-41 (2000). ; 10. Clayton, et al., Trends Neurosci 21, 249-54 (Jun, 1998).

Additional Info

Immunohistochemical/western blot anlysis indicate a high level of specificity for this antiserum for gamma synuclein. Species Crossreactivity: human and rat gamma synuclein.