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SYT (A7) Peptide

SYT (A7) Peptide

Cat no: BS2069P

Supplier: Bioworld Technology, Inc.
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The transcriptional coactivator SYT (synovial translocation protein) contains a conserved amino terminal SNH domain and a carboxy terminal QPGY domain, which is a functioning transcriptional activating sequence. Synovial sarcoma translocation (SSX) proteins, including SSX1-5, are transcriptional repressors that contain a repressor domain in their carboxy termini. SSX proteins are localized to the nucleus and expressed in testis and several types of cancers and, therefore, they are classified as C/T (cancer/testis) antigens. The t(x;18) translocation results in the fusion of the amino terminus of SYT to the carboxy terminus of either SSX1 or SSX2; both fusions result in the production of transcriptional activators. SYT-SSX chimeras are detected in most synovial sarcomas. Synovial sarcomas are responsible for up to 10% of soft issue sarcomas and are histologically characterized as either biphasic or monophasic.Genetic analysis indicates that biphasic synovial sarcomas contain SYT-SSX1 fusions, whereas SYT-SSX2 fusions are found in monophasic synovial sarcomas, providing additional distinguishing characterization of these subtypes.
Catalogue number: BS2069P
Applications: Block/Neutralize/Inhibit
Swiss prot: Q15532
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide SYT (A7). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Protein SSXT; Protein SYT; Synovial sarcoma translocated to X chromosome protein; SS18; SSXT; SYT
Additional info: This peptide can be used with studies using BS2069 SYT (A7) pAb.

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