TACI (Transmembrane Activator and CAML Interactor)

Supplier:

United States Biological

Cat no: T0294-06

TACI (Transmembrane Activator and CAML Interactor)

Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 (1-4) and April/TALL- 2, respectively, (3,5). BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion (1,2). April regulates immunological and non-immunological cell growth. Three receptors, BCMA, TACI, and BAFF-R, for BAFF and April were recently identified (6,7). TACI, like BCMA, binds BAFF and April. TACI and its ligands regulate humoral immune responses, activate NF-kB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases. SOURCE: Rabbit anti-TACI polyclonal antibody was raised against a synthetic peptide mapping at the amino terminus of human TACI (8). \n\nApplications:\nCan be used for detection of TACI by Western blot at 2-5ug/ml.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20 degrees C or colder. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

T0294-06

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Moore PA, et al.,. Science 1999;285:260-3 2. Schneider P, et al J Exp Med 1999;189:1747-56 3. Shu HB, et al. J Leukoc Biol 1999;65:680-3 4. Mukhopadhyay A, et al. J Biol Chem 1999 ;274:15978-81 5. Hahne M,et al J Exp Med. 1998;188(6):1185-90. 6. Gross JA,et al Nature 2000;404:995-9 7. Thompson JS, et al Science. 2001;293:2108-11 8. von Bulow GU, et al Science. 1997;278(5335):138-41. (WD0203).

Additional Info

Recognizes human TACI.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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