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TAL1 (G116) Peptide

TAL1 (G116) Peptide

Cat no: BS3772P

Supplier: Bioworld Technology, Inc.
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Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIalpha, a serine/ threonine protein kinase known to modulate the activity of other bHLH transcription factors.
Catalogue number: BS3772P
Applications: Block/Neutralize/Inhibit
Swiss prot: P17542
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide TAL1 (G116). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: bHLHa17; TAL1; BHLHA17; SCL; TCL5; TAL-1;
Additional info: This peptide can be used with studies using BS3772 TAL1 (G116) pAb.

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