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TAL1 (G116) Peptide

Cat no: BS3772P

TAL1 (G116) Peptide

Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIalpha, a serine/ threonine protein kinase known to modulate the activity of other bHLH transcription factors.

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SPECIFICATIONS

Catalog Number

BS3772P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide TAL1 (G116). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P17542

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS3772 TAL1 (G116) pAb.

Alternative Names

bHLHa17; TAL1; BHLHA17; SCL; TCL5; TAL-1;

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