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Tankyrase (TRF1 interacting ankyrin-related ADP-ribose polymerase)

Cat no: T0900

Tankyrase (TRF1 interacting ankyrin-related ADP-ribose polymerase)

The ~142kD Tankyrase protein is ubiquitously expressed in mammalian cells and is localized to human telomeres. It has homology to ankyrins and to the catalytic domain of poly (adenosine diphosphate-ribose) polymerase (PARP). Tankyrase binds to TRF1 (telomeric repeat binding factor-1), which negatively regulates the maintenance of telomere length.\n\nPositive control: HeLa whole cell extract.

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SPECIFICATIONS

Catalog Number

T0900

Size

100ul

Applications

ELISA

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a serum in PBS, pH 7.2, 0.02% sodium azide.

P Type

Pab

Purity

Purified by affinity chromatography.

Isotype

IgG

References

1. Sbodio, J.I., et al. Biochem. J., Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase). 361: 451-459 (2002) 2. Smith, S., et al. Current Biology, Tankyrase promotes telomere elongation in human cells. 10: 1299-1302 (2000) 3. Smith, S., et al. Science, Tankyrase, a Poly (ADP-Ribose) Polymerase at Human Telomeres. 282: 1484-1487 (1998)

Additional Info

Specific for human Tankyrase

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