TCF-1 (F26) Peptide

Cat no: BS1987P

Supplier: Bioworld Technology, Inc.

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T-cell factor-1 (TCF-1) is a DNA-binding transcriptional activator that isessential for lymphoid cell development. The TCF family of transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, which mediates DNA binding. Several alternative splice variants of TCF-1 have been identified, including TCF-1A, which share a conserved amino terminus and differ in the carboxy terminal sequences. The Wnt mediated signaling pathway induces cytosolic beta-catenin binding to TCF proteins within the nucleus, leading to the enhanced expression of the Wnt target genes. The beta-catenin-TCF complexes are negatively regulated by the adenomatous polyposis coli (APC) tumor suppressor protein, which phosphorylates beta-catenin and, in turn, increases the degradation of cytosolic beta-catenin and inhibits the transcriptional activity of the TCF proteins.

Catalogue number:	BS1987P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P36402
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide TCF-1 (F26). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	Transcription factor 7; TCF-7; T-cell-specific transcription factor 1; T-cell factor 1; TCF-1; TCF7; TCF1
Additional info:	This peptide can be used with studies using BS1987 TCF-1 (F26) pAb.

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TCF-1 (F26) Peptide

Cat no: BS1987P

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