TCF-4/12 (S616) pAb

T cell factors (TCFs) comprise a family of DNA-binding transcriptional activators that are essential for lymphoid cell development. These transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group\n(HMG) 1 box, which mediates DNA binding. TCF-4 mainly localizes in the cytoplasm and is transported into the nucleus directly bound to (beta)-catenin in a cooperative manner. This TCF-4/(beta)-catenin complex induces expression of Wnt target genes, including multiple cancer-associated genes.

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SPECIFICATIONS

Catalog Number

BS1934

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 580-630 of Human TCF-4.

Species

TCF-4/12 (S616) pAb detects endogenous levels of TCF-4/12 protein.

Dilutions

WB: 1:500~1:1000\nIHC: 1:50~1:200

Swiss Prot

P15884/Q99081

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 60 kDa

Alternative Names

ITF 2; ITF2; PTHS; SEF 2; SEF2 1; SEF2 1A; SEF2 1B; SEF2; TCF4; HTF4; HsT17266; HEB; E box binding protein; Transcription factor 12; Transcription factor HTF-4;