TCF-4/12 (S616) Peptide

T cell factors (TCFs) comprise a family of DNA-binding transcriptional activators that are essential for lymphoid cell development. These transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group\n(HMG) 1 box, which mediates DNA binding. TCF-4 mainly localizes in the cytoplasm and is transported into the nucleus directly bound to beta-catenin in a cooperative manner. This TCF-4/beta-catenin complex induces expression of Wnt target genes, including multiple cancer-associated genes.

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SPECIFICATIONS

Catalog Number

BS1934P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide TCF-4/12 (S616). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P15884/Q99081

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS1934 TCF-4/12 (S616) pAb.

Alternative Names

ITF 2; ITF2; PTHS; SEF 2; SEF2 1; SEF2 1A; SEF2 1B; SEF2; TCF4; HTF4; HsT17266; HEB; E box binding protein; Transcription factor 12; Transcription factor HTF-4;