TCP-10 pAb

The protein TCP-1 (t complex polypeptide 1) is a subunit of the heterooligomeric complex CCT (chaperonin containing TCP-1) present in the eukaryotic cytosol. The CCT of eukaryotic cytosol is composed of eight different subunit species, TCP-1 (alpha), (beta), (gamma), (delta), E, ?, n and 0, each encoded by a different gene. Two (zeta)subunits have been described: TCP-1 (zeta)(also designated TCP-1 ?1) and TCP-1 ?2. TCP-1 subunits are proposed to have independent functions in folding its in vivo substrates, the actins and tubulins. TCP-1 was first identified in the mouse as relevant for tail-less and embryonic lethal phenotypes. Sequences homologous to TCP-1 have been isolated in several other species, and the yeast TCP-1 has been shown to encode a molecular chaperone for Actin and Tubulin. TCP-1 found in mammalian cells and yeast plays an important role in the folding of cytosolic proteins.

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SPECIFICATIONS

Catalog Number

BS5960

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 404-449 of Human TCP-10.

Species

TCP-10 pAb detects endogenous levels of TCP-10 protein.

Dilutions

WB: 1:500~1:1000

Swiss Prot

P50990

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 59 kDa

Alternative Names

T-complex protein 1 subunit theta; TCP10; TCP-1 0; TCP1 0; TCP1-0; TCP-1-theta; CCT-theta; CCT0; CCT-0; Renal carcinoma antigen NY-REN-15; CCT8; C21orf112; CCTQ; KIAA0002