TDAG51 (A149) Peptide

Cat no: BS2579P

Supplier: Bioworld Technology, Inc.

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Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immunosurveillance against virus-infected or -transformed cells. Two mechanisms appear to account for this activity, one of which is the perforin-based process. Independently, a FAS-based mechanism involves the transducing molecule FAS (APO-1) and its ligand (FAS-L). The human FAS (APO-1) protein is a 48 kDa cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, and is expressed at high levels in T cells subsequent to crosslinking of the T cell receptor (TCR). A previously undescribed protein, TDAG51, restores activation- induced apoptosis in cells that have lost the ability to display Fas in response to activation. Thus, TDAG51 plays a critical role in T cell apoptosis by coupling TCR

Catalogue number:	BS2579P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	Q8WV24
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide TDAG51 (A149). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	PHLDA1
Additional info:	This peptide can be used with studies using BS2579 TDAG51 (A149) pAb.

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TDAG51 (A149) Peptide

Cat no: BS2579P

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