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TFIIIC110 (R95) Peptide

TFIIIC110 (R95) Peptide

Cat no: BS2107P

Supplier: Bioworld Technology, Inc.
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RNA polymerase (pol) III synthesizes tRNA, 5s rRNA, 7SL RNA and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo, since cells must duplicate its protein components before division. Therefore, in order to maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, which requires the presence of the TFIIIB and TFIIIC2 transcription factor complexes. The TFIIIC2 complex is composed of five subunits, TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, that are overexpressed in adenovirus transformed cells as well as in malignant cells in vivo, such as ovarian carcinomas. TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may be a key component in the deregulation of malignant cells. The TFIIIB complex includes the TATA-binding protein (TBP), TFIIB-related factor 1 (BRF1) and TFIIIB", the expression of which are also upregulated in transformed cells. In many carcinomas, the tumor suppressors retinoblastoma (RB) and p53 are inactivated, which affects their ability to bind and inactivate the function of TFIIIB.
Catalogue number: BS2107P
Applications: Block/Neutralize/Inhibit
Swiss prot: Q8WUA4
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide TFIIIC110 (R95). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: General transcription factor 3C polypeptide 2; TFIIIC110; Transcription factor IIIC 110 kDa subunit; TFIIIC-Beta; Transcription factor IIIC beta subunit
Additional info: This peptide can be used with studies using BS2107 TFIIIC110 (R95) pAb.

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