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TGF (beta)3 (G292) pAb

TGF (beta)3 (G292) pAb

Cat no: BS1363

Supplier: Bioworld Technology, Inc.
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Transforming growth factor betas (TGF(beta)s) were originally discovered due to their ability to promote anchorage-independent growth of rat NRK fibroblasts in the presence of TGF(alpha). It is now realized that TGF(beta)s mediate many cell-cell interactions that occur during embryonic develop ment. Three TGF(beta)s have been identified in mam mals. TGF(beta)1, TGF(beta)2 and TGF(beta)3 are each syn thesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the mol ecules. Biologically active TGF(beta) requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGF(beta)3 protein has approx imately 80% identity to the mature region of both TGF(beta)1 and TGF(beta)2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity.
Catalogue number: BS1363
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P10600
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 261-310 of Human TGF (beta)3.
Species: TGF (beta)3 (G292) pAb detects endogenous levels of pro-TGF(beta)3 (47 kDa) and Cleaved-TGF(beta)3 (13 kDa) protein.
Molecular weight: ~ 13, 47 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Transforming growth factor beta-3; TGF-beta-3; Latency-associated peptide; LAP; TGFB3; TGF(beta)3; TGF (beta)3
Additional info: For research use only, not for use in diagnostic procedure.

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