TGF(beta) RII (I122) pAb

A total of three members of the TGF(beta) family, TGF(beta)1, TGF(beta)2 and TGF(beta)3, have been identified in mammals. Each is synthesized as a latent precursor that is subsequently cleaved forming the 112 amino acid growth factor which becomes active upon dimerization. TGF(beta)s mediate their activity by high affinity binding to the type II receptor (TGF(beta) RII) transmembrane protein with a cytoplasmic serine-threonine kinase domain. For signaling growth inhibition and early gene responses the type II receptor requires both its kinase activity and association with a TGF(beta)-binding protein, designated the type I receptor. Two independent groups have recently described the cloning and sequence analysis of genes encoding TGF(beta) type I receptor proteins designated ALK-5 (T(beta)R-1) and TSR-1, respectively.

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SPECIFICATIONS

Catalog Number

BS1360

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 100-150 of Human TGF(beta) RII.

Species

TGF (beta) Receptor II (I122) pAb detects endogenous levels of TGF (beta) Receptor II protein.

Dilutions

WB: 1:500~1:1000\nIHC: 1:50~1:200

Swiss Prot

P37173

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 65 kDa

Alternative Names

TGF-beta receptor type-2; TGFR-2; TGFR2; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II; TGFBR2