Thrombin R (S42) Peptide

Cat no: BS7067P

Supplier: Bioworld Technology, Inc.

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Additional Information

Thrombin receptor (also designated protease-activated receptor-1 or PAR-1), PAR-2 and PAR-3 compose a distinct class of G protein-coupled receptors activated by proteolysis. Cleavage of these receptors by proteases occurs within the amino-terminal extracellular domain. Thrombin, a serine protease involved in platelet aggregation and blood coagulation, activates the thrombin receptor, resulting in elevated intracellular calcium levels in platelets. Thrombin also cleaves PAR-3 in vitro, suggesting that PAR-3 may be involved in thrombosis or mitogenesis. Thrombin receptor and PAR-4 appear to account for most thrombin signaling in platelets. Activation of PAR-2 in vitro is induced by trypsin, suggesting that PAR-2 is not an alternative thrombin receptor. Cytokines including TNF-alpha and IL-1beta increase PAR-2 expression, indicating PAR-2 involvement in the acute inflammatory response.

Catalogue number:	BS7067P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P25116
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide Thrombin R (S42). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	F2R; CF2R; HTR; PAR-1; PAR1; TR
Additional info:	This peptide can be used with studies using BS7067 Thrombin R (S42) pAb.

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Thrombin R (S42) Peptide

Cat no: BS7067P

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