TIEG2 (F6) pAb

Originally isolated from osteoblastic cells, the TGF-beta-inducible early gene-1 (TIEG1) is a Krupel-like zinc finger transcription factor-encoding gene which regulates cellular growth and differentiation. TIEG1 is regulated as an early response gene by TGF(beta)1. It is expressed in both acinar and ductular epithelial cells from exocrine pancreas and may serve as an early response gene in pancreatic cell lines. Further, overexpression of TIEG1 in TGF(beta)-sensitive epithelial cells induces apoptosis. TIEG1 and EGR-(alpha) are expressedfrom alternate promoters of the same gene. TIEG1 and EGR-(alpha) are both highly expressed in human fetal osteoblast cells. TIEG1 is additionally expressed at high levels in PBLs, spleen and colon, and at lower levels in thymus, small intestine, ovary, prostate and skeletal muscle. The nuclear TIEG2 protein, which shares significant homology with TIEG1, was originally isolated from globin-expressing human fetal eryth-roid cells. TIEG2 is also expressed in fetal liver. Overexpression of TIEG2 in cultured epithelial cells inhibits cellular proliferation; TIEG2 expression is upregulated by TGF(beta)1 and serum deprivation.

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SPECIFICATIONS

Catalog Number

BS1870

Size

100ug/100ul

Applications

IF, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 1-50 of Human TIEG2.

Species

TIEG2 (F6) pAb detects endogenous levels of TIEG2 protein.

Dilutions

WB: 1:500~1:1000\nIHC: 1:50~1:200\nIF: 1:50~1:200

Swiss Prot

O14901

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul