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TIEG2 (F6) Peptide

TIEG2 (F6) Peptide

Cat no: BS1870P

Supplier: Bioworld Technology, Inc.
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Originally isolated from osteoblastic cells, the TGF-beta-inducible early gene-1 (TIEG1) is a Krupel-like zinc finger transcription factor-encoding gene which regulates cellular growth and differentiation. TIEG1 is regulated as an early response gene by TGFbeta1. It is expressed in both acinar and ductular epithelial cells from exocrine pancreas and may serve as an early response gene in pancreatic cell lines. Further, overexpression of TIEG1 in TGFbeta-sensitive epithelial cells induces apoptosis. TIEG1 and EGR-alpha are expressedfrom alternate promoters of the same gene. TIEG1 and EGR-alpha are both highly expressed in human fetal osteoblast cells. TIEG1 is additionally expressed at high levels in PBLs, spleen and colon, and at lower levels in thymus, small intestine, ovary, prostate and skeletal muscle. The nuclear TIEG2 protein, which shares significant homology with TIEG1, was originally isolated from globin-expressing human fetal eryth-roid cells. TIEG2 is also expressed in fetal liver. Overexpression of TIEG2 in cultured epithelial cells inhibits cellular proliferation; TIEG2 expression is upregulated by TGFbeta1 and serum deprivation.
Catalogue number: BS1870P
Applications: Block/Neutralize/Inhibit
Swiss prot: O14901
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide TIEG2 (F6). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: KLF11; FKLF; FKLF1; TIEG-2; TIEG2; TIEG3
Additional info: This peptide can be used with studies using BS1870 TIEG2 (F6) pAb.

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