TK (P7) pAb

Cat no: BS1601

Supplier: Bioworld Technology, Inc.

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Description
Additional Information

Thymidine kinase 2 (TK2) salvages mitochondrial (mt) pyrimidine deoxynucleosides for mtDNA precursor synthesis. TK2 phosphorylates these nucleosides to their corresponding nucleoside monophosphates using a nucleotide triphosphate as a donor. Deficiency of mitochondrial TK2 manifests as severe skeletal myopathy during infancy, due to depletion of mtDNA. Mutant enzyme possesses similar K(m) values to wild type, however, the V(max) is markedly decreased, leading to the decreased enzyme efficiency, which causes the disease.

Catalogue number:	BS1601
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Immunofluorescence, Immunohistochemistry, Western Blot
Size:	100ug/100ul
Swiss prot:	P04183
Dilutions:	WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Synthetic peptide, corresponding to the N-terminus of Human TK.
Species:	TK (P7) pAb detects endogenous levels of TK protein.
Molecular weight:	~ 25 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	TK1; EC 2.7.1.21; TK2
Additional info:	For research use only, not for use in diagnostic procedure.

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TK (P7) pAb

Cat no: BS1601

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