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TLR6, ID (Toll Like Receptor 6, Toll-like Receptor 6 Precursor, CD286)

TLR6, ID (Toll Like Receptor 6, Toll-like Receptor 6 Precursor, CD286)

Cat no: T8050-54M

Supplier: United States Biological
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Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR6 was first identified as a close homolog of TLR1, sharing 69% sequence identify. Like TLR1, TLR6 can form heterodimers with TLR2, and these TLR6:TLR2 dimers coordinate macrophage activation by Gram-positive bacteria and the yeast cell wall particle zymosan. Activation of these complexes not only initiates pro-inflammatory cascades, but also can lead to apoptotic responses. Applications: Suitable for use in ELISA, Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Jurkat cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8050-54M
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Immunocytochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Takeda, K. et al. Annu. Rev. Immunol. 21, 335 (2003). 2. Janeway, CA Jr. et al. Annu. Rev. Immunol. 20, 197 (2002). 3. McGettrick, AF. et al. Mol. Imm. 41, 577 (2004). 4. Takeuchi, O. et al. Gene 231, 59 (1999). 5. Ozinsky, A. et al. Proc. Natl. Acad. Sci. USA 97, 13766 (2000). 6. Into, T. et al. Cell Microbiol. 6, 187 (2004).
Additional info: Recognizes human TLR6.

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