TNF(alpha)-IP8 pAb

TNF(alpha)-IP 8 (tumor necrosis factor, (alpha)-induced protein 8), also known as NFkB-inducible DED-containing protein (NDED), SCC-S2 or TNF-induced protein GG2-1, is a 198 amino acid cytoplasmic protein induced by NFkB and TNF. The induction of TNF(alpha)-IP 8 by TNF is dependent on the activation of NFkB. TNF(alpha)-IP 8 negatively mediates apoptosis and may also play a role in tumor progression. TNF(alpha)-IP 8 specifically inhibits caspase-8 activity, which results in the inhibition of BID cleavage and caspase-3 activation during TNF-mediated apoptosis. TNF(alpha)-IP 8 is expressed at high levels in thymus, bone marrow, lymph node, spleen, thyroid, placenta and various tumor tissues, as well as fetal lung, liver and kidney. TNF(alpha)-IP 8 is present as three isoforms produced by alternative splicing.

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SPECIFICATIONS

Catalog Number

BS5965

Size

100ug/100ul

Applications

IF, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 71-116 of Human TNF(alpha)-IP83.

Species

TNF(alpha)-IP8 pAb detects endogenous levels of TNF(alpha)-IP8 protein.

Dilutions

WB: 1:500~1:1000\nIF: 1:50~1:200

Swiss Prot

O95379

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 23 kDa

Alternative Names

Tumor necrosis factor alpha-induced protein 8; TNF alpha-induced protein 8; Head and neck tumor and metastasis-related protein; MDC-3.13; MDC3.13; NF-kappa-B-inducible DED-containing protein; NDED; SCC-S2; SCC S2; SCCS2; TNF-induced protein GG2-1; TNFAIP8; TNF(alpha) IP8; TNF(alpha)IP8; TNF(alpha)-IP 8