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TNF(alpha)-IP8 pAb

TNF(alpha)-IP8 pAb

Cat no: BS5965

Supplier: Bioworld Technology, Inc.
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TNF(alpha)-IP 8 (tumor necrosis factor, (alpha)-induced protein 8), also known as NFkB-inducible DED-containing protein (NDED), SCC-S2 or TNF-induced protein GG2-1, is a 198 amino acid cytoplasmic protein induced by NFkB and TNF. The induction of TNF(alpha)-IP 8 by TNF is dependent on the activation of NFkB. TNF(alpha)-IP 8 negatively mediates apoptosis and may also play a role in tumor progression. TNF(alpha)-IP 8 specifically inhibits caspase-8 activity, which results in the inhibition of BID cleavage and caspase-3 activation during TNF-mediated apoptosis. TNF(alpha)-IP 8 is expressed at high levels in thymus, bone marrow, lymph node, spleen, thyroid, placenta and various tumor tissues, as well as fetal lung, liver and kidney. TNF(alpha)-IP 8 is present as three isoforms produced by alternative splicing.
Catalogue number: BS5965
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunofluorescence, Western Blot
Size: 100ug/100ul
Swiss prot: O95379
Dilutions: WB: 1:500~1:1000 IF: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 71-116 of Human TNF(alpha)-IP83.
Species: TNF(alpha)-IP8 pAb detects endogenous levels of TNF(alpha)-IP8 protein.
Molecular weight: ~ 23 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Tumor necrosis factor alpha-induced protein 8; TNF alpha-induced protein 8; Head and neck tumor and metastasis-related protein; MDC-3.13; MDC3.13; NF-kappa-B-inducible DED-containing protein; NDED; SCC-S2; SCC S2; SCCS2; TNF-induced protein GG2-1; TNFAIP8; TNF(alpha) IP8; TNF(alpha)IP8; TNF(alpha)-IP 8
Additional info: For research use only, not for use in diagnostic procedure.

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