TNFalpha-IP8 Peptide

TNFalpha-IP 8 (tumor necrosis factor, alpha-induced protein 8), also known as NFkB-inducible DED-containing protein (NDED), SCC-S2 or TNF-induced protein GG2-1, is a 198 amino acid cytoplasmic protein induced by NFkB and TNF. The induction of TNFalpha-IP 8 by TNF is dependent on the activation of NFkB. TNFalpha-IP 8 negatively mediates apoptosis and may also play a role in tumor progression. TNFalpha-IP 8 specifically inhibits caspase-8 activity, which results in the inhibition of BID cleavage and caspase-3 activation during TNF-mediated apoptosis. TNFalpha-IP 8 is expressed at high levels in thymus, bone marrow, lymph node, spleen, thyroid, placenta and various tumor tissues, as well as fetal lung, liver and kidney. TNFalpha-IP 8 is present as three isoforms produced by alternative splicing.

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SPECIFICATIONS

Catalog Number

BS5965P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide TNFalpha-IP8. (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

O95379

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS5965 TNFalpha-IP8 pAb.

Alternative Names

Tumor necrosis factor alpha-induced protein 8; TNF alpha-induced protein 8; Head and neck tumor and metastasis-related protein; MDC-3.13; MDC3.13; NF-kappa-B-inducible DED-containing protein; NDED; SCC-S2; SCC S2; SCCS2; TNF-induced protein GG2-1; TNFAIP8; TNFalpha IP8; TNFalphaIP8; TNFalpha-IP 8