TNFRSF13B/TACI BioAssay(TM) ELISA Kit, Human

Sandwich ELISA quantitative detection kit for Human TNFRSF13B/TACI in cell culture supernates, serum and plasma (heparin, EDTA).\n\nTumor necrosis factor receptor superfamily member 13B, also known as TNFRSF13B or more commonly as TACI, is a transmembrane receptor protein found predominantly on the surface of B cells, which are an important part of the immune system. TACI controls T cell-independent B cell antibody responses, isotype switching, and B cell homeostasis. TACI is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It was originally discovered because of its ability to interact with calcium-modulator and cyclophilin ligand (CAML). TACI was later found to play a crucial role in humoral immunity by interacting with two members of the TNF family: BAFF and APRIL. These proteins signal through TACI inducing activation of several transcription factors including NFAT, AP-1, and NF-kappa-B which then modulate cellular activities. Defects in the function of TACI can lead to immune system diseases.\n\nAssay Range:\n93.8pg/ml-6000pg/ml\n\nSensitivity:\n< 10 pg/ml\n\nCrossreactivity:\nThere is no detectable cross-reactivity with other relevant proteins.\n\nUniprot ID:\nO14836\n\nEntrez Gene ID:\n23495\n\nKit Components:\n96-well plate pre-coated with anti-TNFRSF13B/TACI, Human\nLyophilized recombinant TNFRSF13B/TACI, Human standard, 10ng/tube, 2Ea\nUSB Cat No Kit Component\n143696 Avidin-Biotin-Peroxidase Complex (ABC), 130ul (1:100 dilution)\n143697 Sample diluent buffer, 30ml\n143698 Antibody diluent buffer, 12ml\n143699 ABC diluent buffer, 12ml\n143700 TMB color developing agent, 10ml\n143701 TMB stop solution, 10ml\n\nStorage and Handling:\nStore at 4 degrees C for 6 months, at -20 degrees C for 12 months. Avoid multiple freeze-thaw cycles.

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SPECIFICATIONS

Catalog Number

144068

Size

96Tests

References

1. \"Entrez Gene: TNFRSF13B tumor necrosis factor receptor superfamily, member 13B\".\n2. Wu, Y; Bressette D, Carrell J A, Kaufman T, Feng P, Taylor K, Gan Y, Cho Y H, Garcia A D, Gollatz E, Dimke D, LaFleur D, Migone T S, Nardelli B, Wei P, Ruben S M, Ullrich S J, Olsen H S, Kanakaraj P, Moore P A, Baker K P (November 2000). \"Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS\". J. Biol. Chem. (UNITED STATES) 275 (45): 35478