TNNT2 pAb

Actin is a highly conserved protein that is expressed in all eukaryotic cells. Actin filaments can form both stable and labile structures and are crucial components of microvilli and the contractile apparatus of muscle cells. Myosin is a hexamer of two heavy chains (MHC) and four light chains (MLC) that interacts with Actin to generate the force for diverse cellular movements, including cytokinesis, phagocytosis and muscle contraction. Troponin facilitates the interaction between Actin and Myosin by binding to calcium. Troponin is made up of at least two subunits, which are divergent in cardiac muscle, fast skeletal muscle and slow skeletal muscle. Structures of skeletal muscle troponin are composed of Troponin C (the sensor), Troponin I (the regulator) and Troponin T (the link to the muscle thin filament). Troponin C is dumbbell-shaped and has a hydrophobic pocket that increases the contractile force of muscle fibers. Troponin C has two isoforms: fast and slow. Fast Troponin C has two calcium binding sites, while slow/cardiac Troponin C has a single calcium binding site.

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SPECIFICATIONS

Catalog Number

BS6013

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Recombinant full length Human TNNT2.

Species

TNNT2 pAb detects endogenous levels of TNNT2 protein.

Dilutions

WB: 1:500~1:2000\nIHC: 1:50~1:200

Swiss Prot

P45379

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 35 kDa

Alternative Names

Cardiac muscle troponin T; \nCardiomyopathy dilated 1D (autosomal dominant); \nCardiomyopathy hypertrophic 2; \nCMD1D; \nCMH2; \nCMPD2; \ncTnT; \nLVNC6; \nMGC3889; \nOTTHUMP00000033864; \nOTTHUMP00000033865; \nOTTHUMP00000033866; \nOTTHUMP00000033867; \nOTTHUMP00000033870; \nOTTHUMP00000218095; \nRCM3; \nTNNT 2; \nTNNT2; \nTNNT2; \nTnTC; \nTroponin T cardiac muscle; \nTroponin T type 2 (cardiac); \nTroponin T type 2 cardiac; \nTroponin T; cardiac muscle; \nTroponin T2; \nTroponin T2 cardiac; \n