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Tollip (W151) Peptide

Tollip (W151) Peptide

Cat no: BS9228P


Supplier: Bioworld Technology, Inc.
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Tollip (toll-interacting protein) serves as a suppressor of innate immunity signaling and links the serine/threonine kinase IRAK to the IL-1 receptor complex upon receptor activation. Overexpression of Tollip in HEK-293 cells inhibits NFkB activation in response to TLR2 and TLR4 signaling. Negative regulation of TLR signaling by Tollip may limit the production of proinflammatory mediators during inflammation and infection. Tollip forms a complex with Tom1 to regulate endosomal trafficking of ubiquitinated proteins. The Tollip protein shows ubiquitous expression in mouse.

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