Tollip (toll-interacting protein) serves as a suppressor of innate immunity
signaling and links the serine/threonine kinase IRAK to the IL-1 receptor
complex upon receptor activation. Overexpression of Tollip in HEK-293 cells
inhibits NFkB activation in response to TLR2 and TLR4 signaling. Negative
regulation of TLR signaling by Tollip may limit the production of proinflammatory
mediators during inflammation and infection. Tollip forms a complex
with Tom1 to regulate endosomal trafficking of ubiquitinated proteins. The
Tollip protein shows ubiquitous expression in mouse.
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