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Topo III(beta)-1 (Q84) pAb

Topo III(beta)-1 (Q84) pAb

Cat no: BS1908

Supplier: Bioworld Technology, Inc.
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DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA by transiently breaking and rejoining DNA strands. Although DNA topoisomerase I and DNA topoisomerase II relax both positive and negative supercoils, DNA topoisomerase III relaxes only negative supercoils. DNA topoisomerase III (alpha) exists as a long and a short isoform, which are produced by alternative splicing. DNA topoisomerase III (alpha), which localizes to the nucleolus, is constitutively expressed and remains at high levels throughout the cell cycle in HL-60 cells. DNA topoisomerase III (beta) exists as three isoforms, namely (beta)1, (beta)2 and (beta)3, also produced by alternative splicing. DNA topoisomerase III (beta)1 is expressed in testes, heart and skeletal muscle, whereas (beta)2 is expressed in thymus, kidney and pancreas.
Catalogue number: BS1908
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: O95985
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 51-100 of Human Topo III(beta)-1.
Species: Topo III(beta)-1 (Q84) pAb detects endogenous levels of Topo III(beta)-1 protein.
Molecular weight: ~ 96 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: TOP3B; TOP3B1; DNA topoisomerase 3-beta-1
Additional info: For research use only, not for use in diagnostic procedure.

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