TR(alpha) (A19) pAb

Cat no: BS1364

Supplier: Bioworld Technology, Inc.

0 reviews | Write a Review Pencil

Description
Additional Information

Thyroid hormone nuclear receptors (TRs) are ligand-dependent transcription factors which regulate growth, differentiation and development and represent members of the steroid/retinoic acid superfamily. The two genes encoding TRs identified to date, TR(alpha) and TR(beta), have been mapped to human chromosomes 17 and 3, respectively. TRs bind to thyroid hormone response elements (TREs) with half-site binding motifs in the orientation of palindromes, direct repeats or inverted palindromes. The affinities of binding are both variable and influenced differentially by 3,5,3'-triiodo-L-thyronine (T3). Transcriptional regulation by TRs is also modulated by heterodimerization with TR nuclear accessory proteins, the most extensively characterized of which are the retinoid X receptors (RXR(alpha), RXR(beta) and RXR(gamma)). To a certain extent, this activity is regulated by differential phosphorylation of TRs. Thus, not only are the biological activities of TRs regulated by heterodimerization with RXRs, but in addition, the gene regulatory activities of TRs are linked to other hormonal pathways. TR(alpha)1 can display both a nuclear and undefined cytoplasmic location, and is the only TR that is imported into the mitochondrial matrix.

Catalogue number:	BS1364
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Immunohistochemistry, Western Blot
Size:	100ug/100ul
Swiss prot:	P10827
Dilutions:	WB: 1:500~1:1000 IHC: 1:50~1:200
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Synthetic peptide, corresponding to amino acids 1-50 of Human TR(alpha).
Species:	Thyroid Hormone Receptor (alpha) (A19) pAb detects endogenous levels of Thyroid Hormone Receptor protein.
Molecular weight:	~ 55 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	THRA; AR7; C-ERBA-1; C-ERBA-ALPHA; C-ERBA-ALPHA-2; EAR-7; EAR-7.1; EAR-7.1/EAR-7.2; EAR-7.2; EAR7; ERB-T-1; ERBA; ERBA-ALPHA; ERBA1; MGC000261; MGC43240; NR1A1; THRA1; THRA2; THRA3; TR-ALPHA-1
Additional info:	For research use only, not for use in diagnostic procedure.

See Full Product Listings >

TR(alpha) (A19) pAb

Cat no: BS1364

Get Quote

About Biosave

Product Categories

Information


Get a Quote Direct from Bioworld Technology, Inc.




By submitting this form you agree to your details being passed to Bioworld Technology, Inc. for the purpose of generating the best quote*