TRAF2 pAb

Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain.

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SPECIFICATIONS

Catalog Number

BS6065

Size

100ug/100ul

Applications

IHC, IP, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Recombinant full length Human TRAF2.

Species

TRAF2 pAb detects endogenous levels of TRAF2 protein.

Dilutions

WB: 1:500~1:2000\nIHC: 1:50~1:200\nICC: 1:50~1:200\nIP: 1:50~1:200

Swiss Prot

Q12933

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 56 kDa

Alternative Names

E3 ubiquitin-protein ligase TRAF2; \nMGC:45012; \nTNF receptor associated factor 2; \nTNF receptor-associated factor 2; \nTRAF 2; \nTRAF2; \nTRAF2; \nTRAP 3; \nTRAP; \nTRAP3; \nTumor necrosis factor type 2 receptor associated protein 3; \nTumor necrosis factor type 2 receptor-associated protein 3; \n