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TRIB3 Peptide

TRIB3 Peptide

Cat no: BS60451P

Supplier: Bioworld Technology, Inc.
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TRB-3 (tribbles 3), also called NIPK (neuronal cell death-inducible protein kinase) disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. TRB3 binds to ATF4, inhibiting its transcriptional activation activity, and regulates activation of MAP kinases. In the liver, TRB-3 is a target for PPAR-alpha. Amounts of TRB3 RNA and protein are higher in livers of diabetic mice compared with those in wildtype mice. TRB3 contributes to insulin resistance in individuals with susceptibility to type II diabetes. Highest expression of TRB-3 is in liver, pancreas, peripheral blood leukocytes and bone marrow.
Catalogue number: BS60451P
Applications: Block/Neutralize/Inhibit
Swiss prot: Q96RU7
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide TRIB3. (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Tribbles homolog 3; TRB-3; Neuronal cell death-inducible putative kinase; SINK; p65-interacting inhibitor of NF-kappa-B; C20orf97; NIPK; SKIP3; TRB3; Tribbles 3
Additional info: This peptide can be used with studies using BS60451 TRIB3 pAb.

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