Trk A (E492) Peptide

Cat no: BS1603P

Supplier: Bioworld Technology, Inc.

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TrkA, apparent molecular weight 140 kDa, is a high affinity nerve growth factor (NGF). The Trk proto-oncogene family contains four members, TrkA, TrkB, TrkC, and TrkE, which are variably expressed throughout the central and peripheral nervous systems. TrkA binds to nerve growth factor (NGF) and autophosphorylates on tyrosine residues (Tyr490, Tyr674, Tyr675, Tyr751 and Tyr785) to activate multiple downstream effector proteins. Phosphorylation at Tyr490 is required for Shc association and subsequent activation of the Ras-MAP kinase-signaling cascade, which leads to activation of Elk-1-dependent gene transcription and neurite growth. Phosphorylations at Tyr674 and Tyr675 lie within the catalytic domain of TrkA tyrosine kinase and reflect Trk kinase activity. Additionally, phosphorylation at Tyr751 is required for PI3-kinase association and activation of the Akt signaling cascade.

Catalogue number:	BS1603P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P04629
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide Trk A (E492). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	TrkA ( phospho Y490 ); TrkA; Tyrosine Receptor Kinase A.
Additional info:	This peptide can be used with studies using BS1603 Trk A (E492) pAb.

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Trk A (E492) Peptide

Cat no: BS1603P

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