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UHRF1 (N-terminus) mAb

Cat no: MB0055

UHRF1 (N-terminus) mAb

This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.

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SPECIFICATIONS

Catalog Number

MB0055

Size

100ug/100ul

Applications

WB

Hosts

Mouse

Reactivities

Hum, Mouse

Form

liquid

Purity

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to the N-terminus of Human UHRF1.

Species

This antibody detects endogenous levels of UHRF1 (N-terminus) and does not cross-react with related proteins

Dilutions

WB: 1:1000\nICC: 1:50~200

Swiss Prot

Q96T88

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

Predicted band size:90KDa \nObserved band size:90KDa

Alternative Names

Np95; hNP95; ICBP90; RNF106; FLJ21925; MGC138707; E3 ubiquitin-protein ligase UHRF1; Nuclear protein 95; HuNp95; hNp95; RING finger protein 106;

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