ULK1 belongs to the Ser/Thr protein kinase family. It interacts with GABARAP and GABARAPL2 and is important for vesicle transport and axonal elongation in mammalian neurons. It is involved in starvation-induced autophagy, thus maintaining homeostasis. It is co-localized in many kind of neurons such as pyramidal cells of the hippocampus, mitral cells of the olfactory bulb, and Purkinje cells of the cerebellum.ulK1 plays an essential role in neurite extension of cerebellar granule cells. It is expressed in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.
Applications:
Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Western Blot: 1-3ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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