Urokinase

Cat no: U1790-15C

Supplier: United States Biological

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Urokinase is a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in the Urokinase gene may be associated with late onset Alzheimer disease and also with decreased affinity for fibrin binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg Val bond in plasminogen. The proprotein is cleaved at a Lys Ile bond by plasmin to form a two chain derivative in which a single disulfide bond connects the amino terminal A chain to the catalytically active, carboxy terminal B chain. This two chain derivative is also called HMW uPA (high molecular weight uPA). HMW uPA can be further processed into LMW uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino terminal fragment. LMW uPA is proteolytically active but does not bind to the uPA receptor. Applications: Suitable for use in RIA, ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:5000 Immunohistochemistry (frozen): 1:30-1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Catalogue number:	U1790-15C
Reactivities:	Human
Hosts:	Mouse
Applications:	ELISA, Immunohistochemistry, Western Blot
Size:	1ml
Form:	Supplied as a lyophilized powder. Reconstitute with 1ml ddH2O.
P type:	Mab
Isotype:	IgG1
Purity:	Purified
References:	1. Bashkov, G.V., et al., 1994, Thromos. Res. 74, 321-334. 2. Sakharov, D.V., et al., 1988, Thrombos. Res. 49, 481-488.
Additional info:	Recognizes human Urokinase. Highly specific for urokinase, no crossreactions were found with other serine proteases (tissue plasminogen activator, plasmin, trypsin, chymotrypsin, elastase, thrombin).

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Urokinase

Cat no: U1790-15C

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