Home  >  Products  >  USH1C (Harmonin, Antigen NY-CO-38/NY-CO-37, Autoimmune Enteropathy-related Antigen AIE-75, Protein PDZ-73, Renal Carcinoma Antigen NY-REN-3, Usher Syndrome Type-1C Protein, AIE75)
USH1C (Harmonin, Antigen NY-CO-38/NY-CO-37, Autoimmune Enteropathy-related Antigen AIE-75, Protein PDZ-73, Renal Carcinoma Antigen NY-REN-3, Usher Syndrome Type-1C Protein, AIE75)

USH1C (Harmonin, Antigen NY-CO-38/NY-CO-37, Autoimmune Enteropathy-related Antigen AIE-75, Protein PDZ-73, Renal Carcinoma Antigen NY-REN-3, Usher Syndrome Type-1C Protein, AIE75)

Cat no: U4080-15A

Supplier: United States Biological
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Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:128,000 Western Blot: 0.1-0.3ug/ml, observed in lysates of cell line HEK293 on ~75kD bands Immunohistochemistry (Paraffin): 10ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: U4080-15A
Reactivities: Human, Mouse, Rat, Bovine
Hosts: Goat
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Verpy E, Leibovici M, Zwaenepoel I, Liu XZ, Gal A, Salem N, Mansour A, Blanchard S, Kobayashi I, Keats BJ, Slim R, Petit C. A defect in harmonin, a PDZ domain-containing protein expressed in the inner ear sensory hair cells, underlies Usher syndrome type 1C. Nat Genet. 2000 Sep;26(1):51-5.
Additional info: Recognizes human USH1C. Species sequence homology: Bovine, mouse and rat.

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