Home  >  Products  >  Vascular Endothelial Growth Factor Receptor 1 (VEGFR1, VEGFR-1, Fms-like Tyrosine Kinase 1, FLT1, FLT-1, FLT, FRT, Tyrosine-protein Kinase FRT, Tyrosine-protein Kinase Receptor FLT, Vascular Permeability Factor Receptor)
Vascular Endothelial Growth Factor Receptor 1 (VEGFR1, VEGFR-1, Fms-like Tyrosine Kinase 1, FLT1, FLT-1, FLT, FRT, Tyrosine-protein Kinase FRT, Tyrosine-protein Kinase Receptor FLT, Vascular Permeability Factor Receptor)

Vascular Endothelial Growth Factor Receptor 1 (VEGFR1, VEGFR-1, Fms-like Tyrosine Kinase 1, FLT1, FLT-1, FLT, FRT, Tyrosine-protein Kinase FRT, Tyrosine-protein Kinase Receptor FLT, Vascular Permeability Factor Receptor)

Cat no: V2110-16V

Supplier: United States Biological
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Oncogene FLT belongs to the src gene family and is related to oncogene ROS. Like other members of this family, it shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The sequence structure of the FLT gene resembles that of the FMS gene (colony stimulating factor 1 receptor), hence the name FLT was proposed as an acronym for FMS-like tyrosine kinase. An alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor (VEGF) with high affinity. sFLT1 and FLK1 (VEGFR2) form heterodimers. FLT1 localizes in the 13q12 region of chromosome. FLT1 has been reported mostly in normal lung, but also found in placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. Isoform sFlt1 is strongly expressed in placenta. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 5-10ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Placenta, fetal capillary endothelial cells Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: V2110-16V
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.7, 0.1% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Fms-related Tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor), EC=2.7.10.1
Additional info: Recognizes human FLT1.

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