Vasoactive Intestinal Peptide (VIP)

Vasoactive intestinal peptide (VIP) is a 28 amino acid peptide (human, chr 6q26-q27). It is expressed and secreted by neurons innervating primary and secondary immune organs such as lymph nodes with a MW of 20kD. VIP is a potent neurotrophic factor causes vasodilation, lowers arterial blood pressure, and relaxes the smooth muscle of trachea, stomach and gall bladder. VIP also modulates several T-lymphocyte activities including motility, cytokine production, proliferation and apoptosis, VIP exerts its biological activity by binding to two closely related class II G-protein-coupled receptors VPAC-1 and VPAC-2 beside this VIP has its own receptors VIPR1&2 (Vasoactive Intestinal Polypeptide Receptor 1&2) and VIPRRP (VIP receptor-gene repressor protein). VIP shows similarities to glucagon, secretin and gastric inhibitory peptide (GIP) as such it has been considered a member of the glucagon-secretin family. The VIP is 100% conserved in mouse, rat and human. VIP is considered to be a viable candidate for the development of treatments for rheumatoid arthritis, since treatment with VIP significantly reduced incidence of severity of arthritis, the therapeutic effect of VIP was associated with down regulation of both inflammatory and autoimmune components of the disease.\n\nApplications: \nSuitable for use in ELISA and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution: \nELISA: > 20,000 test/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

V2115

Size

100ul

Applications

ELISA, IHC

Hosts

Rabbit

Reactivities

Hum, Rat, Prc

Form

Supplied as a lyophilized powder. Reconstitue with sterile ddH2O.

P Type

Pab

Purity

Serum

Isotype

IgG

Additional Info

Recognizes human Vasoactive Intestinal Peptide (VIP): 100%, ACTH (human 1-39): 0%, Calcitonin: 0%, PTH (1-34): 0%, Substance P: 0%, Somatostatin: 0%. Species Crossreactivity: porcine and rat. No crossreactivity with mouse tissues.