Home  >  Products  >  Vasoactive Intestinal Polypeptide Receptor 1 (HVR1, II, PACAP-R-2, RCD1, RDC1, VAPC1, VIP-R-1, VIPR, VIPR1, VIRG, VPAC1, PACAP type II receptor, PACAP-R2)
Vasoactive Intestinal Polypeptide Receptor 1 (HVR1, II, PACAP-R-2, RCD1, RDC1, VAPC1, VIP-R-1, VIPR, VIPR1, VIRG, VPAC1, PACAP type II receptor, PACAP-R2)

Vasoactive Intestinal Polypeptide Receptor 1 (HVR1, II, PACAP-R-2, RCD1, RDC1, VAPC1, VIP-R-1, VIPR, VIPR1, VIRG, VPAC1, PACAP type II receptor, PACAP-R2)

Cat no: V2115-20B

Supplier: United States Biological
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VPAC1 is a 52kD seven transmembrane G protein-coupled receptor which mediates VIP (vasoactive intestinal peptide) and PACAP (pituitary adenlyate cyclase activating peptide) function in a variety of tissues. VIP is expressed and secreted by neurones innervating primary and secondary immune organs, and is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. VIP also has potent anti-proliferative and anti-inflammatory functions in the immune system, and VPAC1 is down-regulated under conditions of optimal T cell stimulation. Applications: Suitable for use in Immunohistochemistry (paraffin). Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 20ug/ml Requires antigen retrieval using heat treatment for 20 minutes prior to staining of paraffin sections. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: V2115-20B
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.7, 0.01% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Lara-Marquez, M. et al. (2001) Selective gene expression and activation-dependent regulation of vasoactive intestinal peptide receptor type 1 and type 2 in human T cells. J. Immunol. 166: 2522-2530.
Additional info: Recognizes human VPAC1. Species sequence homology: mouse.

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