Vasoactive Intestinal Polypeptide Receptor 1 (HVR1, II, PACAP-R-2, RCD1, RDC1, VAPC1, VIP-R-1, VIPR, VIPR1, VIRG, VPAC1, PACAP type II receptor, PACAP-R2)

VPAC1 is a 52kD seven transmembrane G protein-coupled receptor which mediates VIP (vasoactive intestinal peptide) and PACAP (pituitary adenlyate cyclase activating peptide) function in a variety of tissues.\n\nVIP is expressed and secreted by neurones innervating primary and secondary immune organs, and is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia.\n\nVIP also has potent anti-proliferative and anti-inflammatory functions in the immune system, and VPAC1 is down-regulated under conditions of optimal T cell stimulation.\n\nApplications:\nSuitable for use in Immunohistochemistry (paraffin). Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (paraffin): 20ug/ml\nRequires antigen retrieval using heat treatment for 20 minutes prior to staining of paraffin sections. Optimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

V2115-20B

Size

50ug

Applications

IHC

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.7, 0.01% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Lara-Marquez, M. et al. (2001) Selective gene expression and activation-dependent regulation of vasoactive intestinal peptide receptor type 1 and type 2 in human T cells. J. Immunol. 166: 2522-2530.

Additional Info

Recognizes human VPAC1. Species sequence homology: mouse.