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VAV2 (D138) Peptide

VAV2 (D138) Peptide

Cat no: BS2443P

Supplier: Bioworld Technology, Inc.
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VAV2 is a ubiquitously expressed structural homolog of the VAV protooncogene that is expressed preferentially in hematopoetic cells. Both proteins are comprised of a Dbl homology (DH) domain with guanosine nucleotide exchange (GEF) activity exclusively directed towards Rho/Rac GTPases, a pleckstrin homology (PH) domain, a calponin-homology (CH) region, an acidic domain (AD) a zinc finger butterfly motif, two SH3 regions and one SH2 domain. GEF activity of RhoA family G proteins is induced by tyrosine phosphorylation in wild type VAV2, and is constitutively activated in N terminus deleted oncogene forms. Constitutive expression of a VAV2 oncoprotein may result in morphological alterations including highly enlarged cells in which karyokinesis and cytokinesis frequently are uncoupled.
Catalogue number: BS2443P
Applications: Block/Neutralize/Inhibit
Swiss prot: P52735
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide VAV2 (D138). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Guanine nucleotide exchange factor VAV2; VAV-2; VAV2
Additional info: This peptide can be used with studies using BS2443 VAV2 (D138) pAb.

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