VHL pAb

Individuals harboring germline mutations in the tumor suppressor gene von Hippel-Lindau (VHL) exhibit an increased susceptibility to a variety of tumors including renal carcinoma, hemangioblastoma of the central nervous system and pheochromocytoma. The Elongin (SIII) complex has been identified as the functional target of the VHL protein. Elongin (SIII) is a heterotrimer composed of a transcriptional active subunit designated Elongin A and two regulatory subunits designated Elongin B and Elongin C. VHL functions by binding to the Elongin B and C subunits, inhibiting the transcriptional efficacy of the Elongin (SIII) complex. Different isoforms of VHL have been observed, encoded by alternatively spliced transcript variants. The molecular weight of each isoform varies between species.

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SPECIFICATIONS

Catalog Number

BS6051

Size

100ug/100ul

Applications

IF, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Recombinant full length Human VHL.

Species

VHL pAb detects endogenous levels of VHL protein.

Dilutions

WB: 1:500~1:2000\nIHC: 1:50~1:200\nIF: 1:50~1:200

Swiss Prot

P40337

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 24 kDa

Alternative Names

Elongin binding protein; \nG7 protein; \nHRCA 1; \nHRCA1; \nProtein G7; \npVHL; \nRCA 1; \nRCA1; \nVHL 1; \nVHL; \nVHL; \nVHL1; \nVHLH; \nVon Hippel Lindau disease tumor suppressor; \nvon Hippel Lindau syndrome; \nvon Hippel Lindau tumor suppressor; \nVon Hippel Lindau tumor suppressor; E3 ubiquitin protein ligase; \nVon Hippel-Lindau disease tumor suppressor; \n