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West Nile Virus, Core (WNV Core, Capsid Protein C)

West Nile Virus, Core (WNV Core, Capsid Protein C)

Cat no: W1018-40C

Supplier: United States Biological
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West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state. Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins which play a major role for WNV entry into target cells. The viral core protein is thought to contribute to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway as delivery of core gene delivery into the striatum of mouse brain and skeletal muscle resulted in cell death and inflammation. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: W1018-40C
Hosts: Rabbit
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Gould, LH., et al., (2004), "West Nile virus: a growing concern?", J. Clin Invest., 113: 1102-1107.2. Chu, J.J., et al., (2005), "Inhibition of West Nile virus entry by using a recombinant domain III from the envelope glycoprotein", J. Gen. Virol., 86: 405-412. 3. Chu, J.J., et al., (2004), "Interaction of West Nile virus with alpha v beta 3 integrin mediates virus entry into cells", J. Biol. Chem., 279: 54533-54541. 4. Yang, J.S., et al., (2002), "Induction of inflammation of West Nile Virus capsid through the caspase-9 apoptotic pathway", Emerg. Infect. Dis., 8: 1379-1384.
Additional info: Recognizes West Nile Virus Core Protein, N-terminal.

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