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YAP (H122) Peptide

Cat no: BS1701P

YAP (H122) Peptide

The Yes-associated protein, otherwise known as YAP, is a 14-3-3-binding molecule that was originally recognized by virtue of its ability to bind to the SH3 domain of Yes. The binding of YAP to 14-3-3 requires the phosphorylation of a homologous serine residue (Ser 112) in the YAP 14-3-3-binding motif. The highly conserved and ubiquitously expressed 14-3-3 proteins regulate differentiation, cell cycle progression and apoptosis by binding intracellular phosphoproteins involved in signal transduction. YAP may link events at the plasma membrane and cytoskeleton to inhibition of transcription in the nucleus in a manner regulated by 14-3-3 proteins. YAP shares homology with the WW domain of TAZ, transcriptional co-activator with PDZ-binding motif, which functions as a transcriptional co-activator by binding to the PPXY motif present in transcription factors. YAP is expressed at high levels in the lung, placenta, prostate, ovary and testis.

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SPECIFICATIONS

Catalog Number

BS1701P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide YAP (H122). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P46937

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS1701 YAP (H122) pAb.

Alternative Names

YAP1; YAP; YAP2; YAP65

SUPPLIER INFO

Bioworld Technology, Inc.

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