YAP (Q295) Peptide

Cat no: BS2000P

Supplier: Bioworld Technology, Inc.

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The Yes-associated protein, otherwise known as YAP, is a 14-3-3-binding molecule that was originally recognized by virtue of its ability to bind to the SH3 domain of Yes. The binding of YAP to 14-3-3 requires the phosphorylation of a homologous serine residue (Ser 112) in the YAP 14-3-3-binding motif. The highly conserved and ubiquitously expressed 14-3-3 proteins regulate differentiation, cell cycle progression and apoptosis by binding intracellular phosphoproteins involved in signal transduction. YAP may link events at the plasma membrane and cytoskeleton to inhibition of transcription in the nucleus in a manner regulated by 14-3-3 proteins. YAP shares homology with the WW domain of TAZ, transcriptional co-activator with PDZ-binding motif, which functions as a transcriptional co-activator by binding to the PPXY motif present in transcription factors. YAP is expressed at high levels in the lung, placenta, prostate, ovary and testis.

Catalogue number:	BS2000P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P46937
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide YAP (Q295). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	YAP1; YAP; YAP2; YAP65
Additional info:	This peptide can be used with studies using BS2000 YAP (Q295) pAb.

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YAP (Q295) Peptide

Cat no: BS2000P

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