ZNF801 pAb

The Myc-associated zinc finger protein MAZ (also designated ZF87, and Pur-1 in mouse) is a transcription factor that participates in both the initiation and termination of transcription of target genes. MAZ functions as a true transcriptional repressor in that it represses transcription independent of the c-Myc promoter. Both MAZ and SP1 bind to the parathyroid hormone (PTH)/ PTH-related peptide receptor promoter, thereby influencing the cell-specific expression of its gene product. MAZ and SP1 also regulate expression from the serotonin 1A receptor gene promoter, suggesting that MAZ may act on a variety of promoters through G-C rich sequences, which serve as binding sites for the SP1 family of transcription factors. Competition between SP1 and MAZ control tissue-specific expression of the PNMT gene. The interaction of MAZ with the transcriptional repressor FAC1 may affect gene regulation in neurodegeneration. MAZ also acts as a growth suppressor protein, in part by affecting the levels of key cell cycle regulatory proteins such as cyclin A and E.

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SPECIFICATIONS

Catalog Number

BS5792

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 201-246 of Human ZNF801.

Species

ZNF801 pAb detects endogenous levels of ZNF801 protein.

Dilutions

WB: 1:500~1:1000

Swiss Prot

P56270

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 48, 60 kDa

Alternative Names

Myc-associated zinc finger protein; MAZI; Pur-1; Purine-binding transcription factor; Serum amyloid A-activating factor-1; SAF-1; Transcription factor Zif87; ZF87; Zinc finger protein 801; MAZ; SAF1; Pur1;