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ZO-2 (Q1112) Peptide

ZO-2 (Q1112) Peptide

Cat no: BS3192P

Supplier: Bioworld Technology, Inc.
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Tight junctions are complexes of proteins that create intercellular boundaries between the plasma membrane domains of epithelial and endothelial cells. Many of the tight junction-associated proteins are members of the membraneassociated guanylate kinase (MAGUK) family and include Occludin, ZO-1, ZO-2 and ZO-3. These proteins are thought to have both structural and signaling roles, and are characteristically defined by three protein-protein interaction modules: the PDZ domain, the SH3 domain and the guanylate kinase (GuK) domain. ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with Claudin, Occludin and F-Actin at tight junction stands, where they provide a linkage between the Actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue.
Catalogue number: BS3192P
Applications: Block/Neutralize/Inhibit
Swiss prot: Q9UDY2
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide ZO-2 (Q1112). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Tight junction protein ZO-2; Tight junction protein 2; Zona occludens protein 2; Zonula occludens protein 2; X104; ZO2; TJP2
Additional info: This peptide can be used with studies using BS3192 ZO-2 (Q1112) pAb.

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