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Chromomycin A3 is the major component of the chromomycin complex of the aureolic acid class, isolated from several Streptomyces species and first reported in...
Isolated from Cercosporidium henningsii, cercosporamide was originally identified as a host-selective phytotoxin and broad spectrum antifungal agent. More...
Brevicompanine B is a diketopiperazine related metabolite produced by Penicillium and Aspergillus species. Brevicompanine B was found to be active against...
Antibiotic LL Z1640-4 is a cis-enol resorcylic acid lactone first reported in 1978 exhibiting both antiviral and antiprotozoan activity. More recently,...
Antibiotic LL Z1640-2 a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1...
Antibiotic TS155-2 is a macrocyclic lactone related to hygrolidin but produced by a different Streptomyces species. Antibiotic TS155-2 is reported to be an...
Calcimycin is a potent calcium ionophore isolated from Streptomyces chartreusis in 1974. Calcimycin is a spiroketal substituted by pyrollic and benzoxazolyl...
Aflatoxin B2 is a minor analogue of the blue fluorescent family of bisfuranocoumarin mycotoxins produced by Aspergillus flavus and related species....
Aflatoxin G2 is a minor analogue of the green fluorescent family of bisfuranocoumarin mycotoxins produced by Aspergillus flavus and related species....
Aflatoxin G1 is the major analogue of the green fluorescent family of bisfuranocoumarin mycotoxins produced by Aspergillus flavus and related species....
Aflatoxin B1 is the major analogue of a family of bisfuranocoumarin mycotoxins produced by Aspergillus flavus and related species. Alfatoxin B1 exhibits a...
The peptide Polymyxin B (PMB) is a cyclic amphipathic peptide antibiotic that binds to endotoxins (lipopolysaccharide, LPS). Binding of PMB to LPS results in...
Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (OxPAPC) is a prototypic biologically active oxidized phospholipid first isolated from LDL...
1-palmitoyl-2-arachidonoyl-sn-phosphatidylcholine (PAPC), is a naturally occuring phospholipid containing polyunsaturated arachidonic acid, which is a common...
STAT3 protein is a transcription factor expressed in most cell types and is activated by multiple cytokines and growth factors including: IFN-a, IL-10, IL-6,...
An important inhibitory neurotransmitter. Foods that contain g-aminobutyric acid (GABA) can have an immediate effect of suppressing autonomic nerve activity...
A potent inhibitor of Smoothened (SMO), a key mediator of Hedgehog (Hh) signaling pathway. Inhibition of SMO renders the transcription factor GLI inactive,...
A potent, reversible proteasome inhibitor with Ki of 21nM for 20S proteasome and 35nM for 26S proteasome. The inhibition of proteasome was through specific...
A cell-permeable inhibitor of calpain 1 (Ki =120nM) and calpain 2 (Ki =230nM). Also potently inhibits cathepsin B (Ki =100nM), and cathepsin L (Ki=0.6nM)....
An inhibitor of monoamine oxidase (MAO) and prostacyclin synthase. Potently suppresses the enzymatic activity of Lysine-Specific Demethylase 1 (LSD1) (IC50...
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